Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice

Figure 8 Effect of emodin on gut microbiota in mice with α-naphthylisothiocyanate-induced cholestasis liver injury. A: Alpha diversity (Chao and Shannon indices) of bacteria in control, α-naphthylisothiocyanate-treated and emodin-treated mice; B: Community distribution at the phylum level; C: Community distribution at the genus level; D: Principal co-ordinates analysis of different groups at the genus level; E-H: Proportion of differential microbiota. Data were analyzed via the Wilcoxon rank-sum test. ^aP < 0.01 vs control group, ^bP < 0.001 vs control group, ^cP < 0.05 vs α-naphthylisothiocyanate group, and ^dP < 0.01 vs α-naphthylisothiocyanate group. Cont: Control; Emo: Emodin; ANIT: Α-naphthylisothiocyanate; PCoA: Principal co-ordinates analysis.