Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice

doi:10.3748/wjg.117819

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 28, 2026; 32(44): 117819
Published online Nov 28, 2026. doi: 10.3748/wjg.117819

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Figure 3 Analyses of differential metabolites in plasma and liver by ultra-high-performance liquid chromatography/quadrupole-Orbitrap-mass spectrometry-based metabolomics. A: Principal component analysis score plots; B: Orthogonal partial least square discriminate analysis, permutation test and S-plot of plasma; C: Orthogonal partial least square discriminate analysis, permutation test and S-plot of liver. Cont: Control; Emo: Emodin; ANIT: Α-naphthylisothiocyanate; PCA: Principal component analysis; OPLS-DA: Orthogonal partial least square discriminate analysis; QC: Quality control.

Citation: Wang CX, Wang LM, Fu ZF, Zhao X, Han LF, Lou YF. Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice. World J Gastroenterol 2026; 32(44): 117819
URL: https://www.wjgnet.com/1007-9327/full/v32/i44/117819.htm
DOI: https://dx.doi.org/10.3748/wjg.117819

Wang CX, Wang LM, Fu ZF, Zhao X, Han LF, Lou YF. Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice. World J Gastroenterol 2026; 32(44): 117819 [DOI: 10.3748/wjg.117819]

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