EIF5B/mitogen-activated protein kinase 1 axis drives tumor progression and confers dual resistance to chemotherapy and immunotherapy in colonic adenocarcinoma

doi:10.3748/wjg.121829

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 21, 2026; 32(43): 121829
Published online Nov 21, 2026. doi: 10.3748/wjg.121829

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Figure 6 Associations of eukaryotic translation initiation factor 5B expression with drug sensitivity, along with the underlying signaling pathway. A-D: Positive correlations between the sensitivity scores of oxaliplatin 1089, oxaliplatin 1806, 5-fluorouracil 1073, and irinotecan 1088 and EIF5B mRNA expression; E-H: The correlation of individual genes with sensitivity score was analyzed; I: Kyoto Encyclopedia of Genes and Genomes enrichment analyses of sensitivity scores. Spearman’s correlation analysis was applied for correlation. MAPK: Mitogen-activated protein kinase.

Citation: Li WX, Shi QZ, Mu YH, Li CL, Khan S, Zhao WC, Han N. EIF5B/mitogen-activated protein kinase 1 axis drives tumor progression and confers dual resistance to chemotherapy and immunotherapy in colonic adenocarcinoma. World J Gastroenterol 2026; 32(43): 121829
URL: https://www.wjgnet.com/1007-9327/full/v32/i43/121829.htm
DOI: https://dx.doi.org/10.3748/wjg.121829

Li WX, Shi QZ, Mu YH, Li CL, Khan S, Zhao WC, Han N. EIF5B/mitogen-activated protein kinase 1 axis drives tumor progression and confers dual resistance to chemotherapy and immunotherapy in colonic adenocarcinoma. World J Gastroenterol 2026; 32(43): 121829 [DOI: 10.3748/wjg.121829]

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