EIF5B/mitogen-activated protein kinase 1 axis drives tumor progression and confers dual resistance to chemotherapy and immunotherapy in colonic adenocarcinoma

Figure 1 Eukaryotic translation initiation factor 5B was upregulated in cancerous tissue and predicted a poor prognosis for patients with colonic adenocarcinoma. A-F: Analyses based on databases demonstrated significantly higher eukaryotic translation initiation factor 5B (EIF5B) mRNA expression in colonic adenocarcinoma (COAD) cancer tissues than in paracancerous tissues; G: Representative immunohistochemical staining of paired normal and tumor specimens from patients with COAD. EIF5B was undetectable in normal colonic tissue, whereas COAD tissues exhibited high EIF5B expression; H: Kaplan-Meier method was employed to assess the correlation of EIF5B expression with the prognosis of patients with COAD. All photomicrographs were captured at 200 × magnification. Independent-samples t-test, paired-samples t-test, and non-parametric tests were used for two-group comparisons. ^aP < 0.05. ^bP < 0.01. ^dP < 0.0001. TCGA: The Cancer Genome Atlas; COAD: Colonic adenocarcinoma.