EIF5B/mitogen-activated protein kinase 1 axis drives tumor progression and confers dual resistance to chemotherapy and immunotherapy in colonic adenocarcinoma

doi:10.3748/wjg.121829

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 21, 2026; 32(43): 121829
Published online Nov 21, 2026. doi: 10.3748/wjg.121829

Table 3 The correlation between clinical characteristics of colonic adenocarcinoma patients and eukaryotic translation initiation factor 5B expression

Characteristics	n = 70	*EIF5B*		χ² value	P value
Characteristics	n = 70	Low	High	χ² value	P value
T stage				4.686	0.030
T1 + T2	15	11	4
T3 + T4	55	23	32
N stage				0.278	0.598
N0	41	21	20
N1 + N2	29	13	16
M stage				0.051	0.822
M0	59	29	30
M1	11	5	6

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Citation: Li WX, Shi QZ, Mu YH, Li CL, Khan S, Zhao WC, Han N. EIF5B/mitogen-activated protein kinase 1 axis drives tumor progression and confers dual resistance to chemotherapy and immunotherapy in colonic adenocarcinoma. World J Gastroenterol 2026; 32(43): 121829
URL: https://www.wjgnet.com/1007-9327/full/v32/i43/121829.htm
DOI: https://dx.doi.org/10.3748/wjg.121829

Li WX, Shi QZ, Mu YH, Li CL, Khan S, Zhao WC, Han N. EIF5B/mitogen-activated protein kinase 1 axis drives tumor progression and confers dual resistance to chemotherapy and immunotherapy in colonic adenocarcinoma. World J Gastroenterol 2026; 32(43): 121829 [DOI: 10.3748/wjg.121829]

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