Crosstalk between neutrophils and hepatic stellate cells in liver injury and repair: Mechanisms and implications

doi:10.3748/wjg.121310

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 21, 2026; 32(43): 121310
Published online Nov 21, 2026. doi: 10.3748/wjg.121310

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Figure 2 Time-stratified neutrophil polarization and hepatic stellate cells activation after liver injury. Neutrophils shift from N1 (0-24 hours; pro-inflammatory) to N2 (48-72 hours; reparative). Hepatic stellate cells activate during this transition and peak in repair, driving extracellular matrix remodeling and collagen synthesis; persistent activation may sustain fibrosis. ROS: Reactive oxygen species; HSC: Hepatic stellate cell; IL: Interleukin; TGF-β: Transforming growth factor-β; DAMPs: Damage-associated molecular patterns.

Citation: Lian YJ, Li MY, Wang L, Gao YW, Zhu D, Lyu WL. Crosstalk between neutrophils and hepatic stellate cells in liver injury and repair: Mechanisms and implications. World J Gastroenterol 2026; 32(43): 121310
URL: https://www.wjgnet.com/1007-9327/full/v32/i43/121310.htm
DOI: https://dx.doi.org/10.3748/wjg.121310

Lian YJ, Li MY, Wang L, Gao YW, Zhu D, Lyu WL. Crosstalk between neutrophils and hepatic stellate cells in liver injury and repair: Mechanisms and implications. World J Gastroenterol 2026; 32(43): 121310 [DOI: 10.3748/wjg.121310]

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