Influence of pregnancy on outcomes of inflammatory bowel disease and treatment discontinuation

doi:10.3748/wjg.120573

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 21, 2026; 32(43): 120573
Published online Nov 21, 2026. doi: 10.3748/wjg.120573

Table 4 Demographics, clinical characteristics, and laboratory data of the whole study group and subgroups according to treatment discontinuation, median (interquartile range)/n (%)

	CD-study group (n = 20)	No-activation (n = 10)	Activation (n = 10)	P value	UC-study group (n = 37)	No-activation (n = 22)	Activation (n = 15)	P value
Age at onset of disease, years	20.5 (17.25-24.75)	19.5 (18-24)	21.5 (14.25-26)	0.970	23 (19.5-26)	23 (19.75-26.25)	22 (19-25)	0.675
CRP (mg/L)	17.1 (5.25-60)	17.1 (6.8-22.5)	34.5 (4-101.75)	0.597	6.14 (5-10.75)	5 (5-11.5)	7.4 (5-10)	0.883
HB (g/dL)	10.65 (9.68-12.6)	10.85 (10.28-12.7)	10.55 (9.18-13.05)	0.677	11.7 (10.1-12)	11.8 (10.2-12)	11.7 (10-12)	0.948
Albumin (g/dL)	4.15 (3.85-4.48)	4.3 (4.03-4.43)	4 (3.28-4.6)	0.287	4 (4-4.3)	4 (4-4.3)	4 (4-4.4)	0.797
Cause of treatment discontinuation				0.582				0.012^a
None	16 (80)	7 (70)	9 (90)		25 (67.6)	19 (86.4)	6 (40)
Patient choice	4 (20)	3 (30)	1 (10)		9 (24.3)	2 (9.1)	7 (46.7)
Physician advisement					3 (8.1)	1 (4.5)	2 (13.3)
Salvage therapy				0.303				< 0.001^b
Steroid needed	5 (25)		4 (40)		8 (21.6)		8 (53.3)
Cause of activation
None	10 (50)	10 (100)			22 (59.5)	22 (100)
Pregnancy	9 (45)		9 (90)		10 (27)		10 (66.7)
Treatment discontinuation	1 (5)		1 (10)		3 (8.1)		3 (20)
Both					2 (5.4)		2 (13.3)
Mode of delivery				1				0.405
Live birth	18 (90)	9 (90)	9 (90)		36 (97.3)	22 (100)	14 (93.3)
NA	6 (30)	4 (40)	2 (20)		8 (21.6)	1 (4.5)	7 (46.7)
Normal delivery	4 (20)	1 (10)	3 (30)		14 (37.8)	12 (54.5)	2 (13.3)
Cesarean section	8 (40)	4 (40)	4 (40)		14 (37.8)	9 (40.9)	5 (33.3)
Abortion	2 (10)	1 (10)	1 (10)		1 (2.7)		1 (6.7)

^aP < 0.05.

^bP < 0.001.

CRP: C-reactive protein; HB: Hemoglobin; NA: Not available; CD: Crohn’s disease; UC: Ulcerative colitis.

Full Size Table

Citation: Ozturk O, Durak MB, Cagir Y, Ergul M, Keskin ET, Yilmaz E, Acun KC, Atay A, Yuksel I. Influence of pregnancy on outcomes of inflammatory bowel disease and treatment discontinuation. World J Gastroenterol 2026; 32(43): 120573
URL: https://www.wjgnet.com/1007-9327/full/v32/i43/120573.htm
DOI: https://dx.doi.org/10.3748/wjg.120573

Ozturk O, Durak MB, Cagir Y, Ergul M, Keskin ET, Yilmaz E, Acun KC, Atay A, Yuksel I. Influence of pregnancy on outcomes of inflammatory bowel disease and treatment discontinuation. World J Gastroenterol 2026; 32(43): 120573 [DOI: 10.3748/wjg.120573]

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