Aurantii Fructus Immaturus Flavonoid tablets for functional dyspepsia: A multicenter, double-blind, dose-exploring IIb randomized controlled trial

doi:10.3748/wjg.122218

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 14, 2026; 32(42): 122218
Published online Nov 14, 2026. doi: 10.3748/wjg.122218

Table 2 Changes of postprandial 2-hour gastric emptying rate (%) and gastric half-emptying time (hours) before and after treatment, mean ± SD

Outcomes		High-dose group	Median-dose group	Low-dose group	Placebo group	F value	P value
Gastric emptying rate	N (N miss)	17 (50)	15 (51)	17 (50)	15 (52)	1.10	0.355
		5.78 ± 9.83	5.01 ± 10.07	4.24 ± 10.99	-0.35 ± 10.13
	MD (95%CI) vs placebo	6.13 (-3.49, 15.75)	5.35 (-4.56, 15.27)	4.58 (-5.04, 14.20)
Gastric half-emptying time	N (N miss)	17 (50)	15 (51)	17 (50)	15 (52)	1.02	0.389
		-0.75 ± 1.05	-0.75 ± 2.40	-0.23 ± 1.21	0.01 ± 0.96
	MD (95%CI) vs placebo	-0.77 (-2.17, 0.64)	-0.76 (-2.21, -0.69)	-0.24 (-1.65, 1.16)

CI: Confidence interval; MD: Mean difference.

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Citation: Wan Q, Wang YY, Li XY, Liu Y, Jia BY, Han M. Aurantii Fructus Immaturus Flavonoid tablets for functional dyspepsia: A multicenter, double-blind, dose-exploring IIb randomized controlled trial. World J Gastroenterol 2026; 32(42): 122218
URL: https://www.wjgnet.com/1007-9327/full/v32/i42/122218.htm
DOI: https://dx.doi.org/10.3748/wjg.122218

Wan Q, Wang YY, Li XY, Liu Y, Jia BY, Han M. Aurantii Fructus Immaturus Flavonoid tablets for functional dyspepsia: A multicenter, double-blind, dose-exploring IIb randomized controlled trial. World J Gastroenterol 2026; 32(42): 122218 [DOI: 10.3748/wjg.122218]

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