Aurantii Fructus Immaturus Flavonoid tablets for functional dyspepsia: A multicenter, double-blind, dose-exploring IIb randomized controlled trial

doi:10.3748/wjg.122218

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 32, Issue 42

This Article

(0)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 14, 2026; 32(42): 122218
Published online Nov 14, 2026. doi: 10.3748/wjg.122218

Table 1 Demographics and baseline characteristics, mean ± SD/n (%)

Variables		High-dose group, n = 67	Median-dose group, n = 66	Low-dose group, n = 67	Placebo group, n = 67	Statistics	P value
Age (years)		40.51 ± 12.98	40.86 ± 13.95	41.56 ± 13.80	39.24 ± 12.87	F = 0.35	0.788
Gender	Male	21 (31.34)	22 (33.33)	29 (43.28)	30 (44.78)	χ² = 3.962	0.266
Gender	Female	46 (68.66)	44 (66.67)	38 (56.72)	37 (55.22)	χ² = 3.962	0.266
Height (cm)		162.84 ± 7.68	163.03 ± 6.75	164.16 ± 8.54	163.76 ± 8.59	F = 0.414	0.745
Weight (kg)		59.25 ± 8.05	61.31 ± 8.07	59.43 ± 8.33	60.63 ± 9.25	F = 0.903	0.441
Source	Outpatient	67 (100.00)	66 (100.00)	67 (100.00)	67 (100.00)
Duration (months)	N (N miss)	45 (22)	51 (15)	51 (16)	49 (18)	H = 3.000	0.392
Duration (months)	Median (P₂₅, P₇₅)	28.10 (14.90, 48.10)	24.60 (12.90, 42.60)	25.40 (11.80, 55.30)	22.70 (10.90, 32.10)	H = 3.000	0.392
Western medicine treatment history	No	48 (71.64)	51 (77.27)	53 (79.10)	53 (79.10)	Fisher’s exact test	0.727
Western medicine treatment history	Yes	19 (28.36)	15 (22.73)	14 (20.90)	14 (20.90)	Fisher’s exact test	0.727
TCM treatment history	No	48 (71.64)	48 (72.73)	52 (77.61)	52 (77.61)	Fisher’s exact test	0.801
TCM treatment history	Yes	19 (28.36)	18 (27.27)	15 (22.39)	15 (22.39)	Fisher’s exact test	0.801
Comorbidities	No	56 (83.58)	51 (77.27)	64 (95.52)	60 (89.55)	Fisher’s exact test	0.012
Comorbidities	Yes	11 (16.42)	15 (22.73)	3 (4.48)	7 (10.45)	Fisher’s exact test	0.012
Smoking history	No	60 (89.55)	59 (89.39)	64 (95.52)	58 (86.57)	Fisher’s exact test	0.321
Smoking history	Yes	7 (10.45)	7 (10.61)	3 (4.48)	9 (13.43)	Fisher’s exact test	0.321
Physical examination	Normal	67 (100.00)	66 (100.00)	67 (100.00)	66 (98.51)	Fisher’s exact test	> 0.999
Physical examination	Abnormal	0 (0.00)	0 (0.00)	0 (0.00)	1 (1.49)	Fisher’s exact test	> 0.999
TCM syndrome patterns	Liver-stomach disharmony	28 (41.79)	21 (31.82)	17 (25.37)	20 (29.85)	H = 11.431	0.247
	Spleen-stomach damp-heat	16 (23.88)	20 (30.30)	28 (41.79)	24 (35.82)
	Food stagnation	13 (19.40)	9 (13.64)	9 (13.43)	6 (8.96)
	Spleen-stomach weakness	10 (14.93)	16 (24.24)	13 (19.40)	17 (25.37)
Postprandial fullness	0 points	0 (0.00)	0 (0.00)	1 (1.49)	0 (0.00)	H = 2.198	0.531
	1 point	11 (16.42)	10 (15.15)	13 (19.40)	12 (17.91)
	2 points	38 (56.72)	38 (57.58)	39 (58.21)	43 (64.18)
	3 points	18 (26.87)	18 (27.27)	14 (20.90)	12 (17.91)
Early satiety	0 points	1 (1.49)	0 (0.00)	2 (2.99)	0 (0.00)	H = 2.672	0.446
	1 point	20 (29.85)	24 (36.36)	26 (38.81)	22 (32.84)
	2 points	35 (52.24)	35 (53.03)	33 (49.25)	39 (58.21)
	3 points	11 (16.42)	7 (10.61)	6 (8.96)	6 (8.96)
Upper abdominal burning sensation	0 points	7 (10.45)	6 (9.09)	8 (11.94)	4 (5.97)	H = 0.780	0.854
	1 point	28 (41.79)	28 (42.42)	25 (37.31)	30 (44.78)
	2 points	27 (40.30)	28 (42.42)	30 (44.78)	23 (34.33)
	3 points	5 (7.46)	4 (6.06)	4 (5.97)	10 (14.93)
Upper abdominal pain visual analog scale	Median (P₂₅, P₇₅)	5.00 (4.00, 6.00)	5.00 (4.00, 5.00)	4.00 (3.00, 5.20)	4.00 (3.00, 6.00)	H = 0.947	0.423
Gastric emptying rate (%)	N (N miss)	17 (50)	17 (49)	17 (50)	17 (50)	F = 0.962	0.419
Gastric emptying rate (%)		31.46 ± 9.14	29.43 ± 10.72	31.94 ± 7.30	34.92 ± 10.69
Gastric half-emptying time (hours)	N (N miss)	17 (50)	17 (49)	17 (50)	17 (50)	F = 1.707	0.175
Gastric half-emptying time (hours)		3.64 ± 1.07	4.07 ± 2.04	3.38 ± 0.95	3.09 ± 0.85

TCM: Traditional Chinese medicine.

Full Size Table

Citation: Wan Q, Wang YY, Li XY, Liu Y, Jia BY, Han M. Aurantii Fructus Immaturus Flavonoid tablets for functional dyspepsia: A multicenter, double-blind, dose-exploring IIb randomized controlled trial. World J Gastroenterol 2026; 32(42): 122218
URL: https://www.wjgnet.com/1007-9327/full/v32/i42/122218.htm
DOI: https://dx.doi.org/10.3748/wjg.122218

Wan Q, Wang YY, Li XY, Liu Y, Jia BY, Han M. Aurantii Fructus Immaturus Flavonoid tablets for functional dyspepsia: A multicenter, double-blind, dose-exploring IIb randomized controlled trial. World J Gastroenterol 2026; 32(42): 122218 [DOI: 10.3748/wjg.122218]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.