Low accuracy and interobserver/intraobserver agreement for colorectal sessile serrated lesions: A multicenter diagnostic study

doi:10.3748/wjg.120411

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 32, Issue 42

This Article

(0)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 14, 2026; 32(42): 120411
Published online Nov 14, 2026. doi: 10.3748/wjg.120411

Table 4 Logistic regression analysis for diagnostic consensus for sessile serrated lesion and sessile serrated lesion with dysplasia, mean ± SD/n (%)

Variable		Consensus group	Discordance group	Univariate analysis	Multivariate analysis
Variable		n = 54	n = 99	P value	P value	OR (95%CI)
Age (years)		53.22 ± 11.50	55.59 ± 13.89	0.274	-	-
Sex	Female	19 (35.2)	38 (38.4)	0.696	-	-
Flat or sessile morphology	Yes	50 (92.6)	95 (96.0)	0.371	-	-
Lesion size¹	≤ 0.5 cm	15 (34.1)	32 (38.1)	0.164	-	-
Crypt orientation	Cross-sectional	4 (7.4)	37 (37.4)	< 0.001^a	0.006^b	5.27 (1.61-17.18)
Serrated region	Lower 1/3 crypt	52 (96.3)	73 (73.7)	0.001^a	0.044^b	0.20 (0.04-0.96)
Crypt dilation	Lower 1/3 crypt	53 (98.1)	73 (73.7)	< 0.001^a	-	-
Proliferative zone	Basal crypt	1 (1.9)	6 (6.1)	0.234	-	-
Abnormal crypt architecture	Yes	53 (98.1)	70 (70.7)	< 0.001^a	0.033^b	0.37 (0.15-0.92)
Number of serrated crypts	> 3	22 (40.7)	22 (22.2)	0.016^a	-	-
Nuclear alteration	Yes	4 (7.4)	34 (34.3)	< 0.001^a	< 0.001^b	10.45 (3.01-36.30)
Cytoplasmic eosinophilia	Prominent	24 (44.4)	43 (43.4)	0.904	-	-

¹Polyp size data of some cases are missing.

^aP < 0.1.

^bP < 0.05.

OR: Odds ratio.

Full Size Table

Citation: Hu H, Zhao SB, Zhao YD, Sui XY, Zhang S, Wei JH, Liu XF, Shi YC, Tang L, Zhang BB, Feng Z, Cheng W, Zhu MH, Zhu Z, Li ZS, He MX, Bai Y, Zhang J. Low accuracy and interobserver/intraobserver agreement for colorectal sessile serrated lesions: A multicenter diagnostic study. World J Gastroenterol 2026; 32(42): 120411
URL: https://www.wjgnet.com/1007-9327/full/v32/i42/120411.htm
DOI: https://dx.doi.org/10.3748/wjg.120411

Hu H, Zhao SB, Zhao YD, Sui XY, Zhang S, Wei JH, Liu XF, Shi YC, Tang L, Zhang BB, Feng Z, Cheng W, Zhu MH, Zhu Z, Li ZS, He MX, Bai Y, Zhang J. Low accuracy and interobserver/intraobserver agreement for colorectal sessile serrated lesions: A multicenter diagnostic study. World J Gastroenterol 2026; 32(42): 120411 [DOI: 10.3748/wjg.120411]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.