Real-world effectiveness and safety of risankizumab in multirefractory Crohn’s disease: A multicenter AIRIS-Crohn registry analysis

doi:10.3748/wjg.119693

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 14, 2026; 32(42): 119693
Published online Nov 14, 2026. doi: 10.3748/wjg.119693

Table 1 Baseline characteristics and disease features, n (%)

Baseline characteristic	Patients (n = 205)
Mean (years), median (interquartile range)	49.2 (38-61)
Sex
Female	107 (52.2)
Male	98 (47.8)
Smoking status
Active	49 (23.9)
Former	56 (27.3)
Never	100 (48.8)
Disease location
Ileal	100 (48.8)
Colonic	16 (7.8)
Ileocolonic	88 (42.9)
Upper gastrointestinal	14 (6.9)
Extraintestinal manifestations	125 (61.0)
Perianal disease	36 (17.6)
Prior intestinal resection	80 (39.4)
Previous biologics failed
Infliximab	125 (61.0)
Adalimumab	145 (70.7)
Vedolizumab	47 (22.9)
Ustekinumab	167 (81.5)
Certolizumab	7 (3.4)
Upadacitinib	21 (10.2)
Concomitant corticosteroids	57 (28.4)
Concomitant immunomodulators	5 (2.5)
Herpes zoster vaccination	87 (44.2)

Full Size Table

Citation: Caballero-Mateos AM, Valdés-Delgado T, Olmedo-Martín R, Romero-Cara P, Martín-Rodríguez MDM, Lancho Muñoz A, Moreno-Barrueco M, Gijón-Villanova R, Fernández-Moreno N, Rodríguez-González FJ, Hernández-Martínez Á, Trapero-Martínez AM, Bejarano-García A, Benitez Cantero JM, Mata-Perdigón FJ, Sáez-Díaz A, Argüelles-Arias F. Real-world effectiveness and safety of risankizumab in multirefractory Crohn’s disease: A multicenter AIRIS-Crohn registry analysis. World J Gastroenterol 2026; 32(42): 119693
URL: https://www.wjgnet.com/1007-9327/full/v32/i42/119693.htm
DOI: https://dx.doi.org/10.3748/wjg.119693

Caballero-Mateos AM, Valdés-Delgado T, Olmedo-Martín R, Romero-Cara P, Martín-Rodríguez MDM, Lancho Muñoz A, Moreno-Barrueco M, Gijón-Villanova R, Fernández-Moreno N, Rodríguez-González FJ, Hernández-Martínez Á, Trapero-Martínez AM, Bejarano-García A, Benitez Cantero JM, Mata-Perdigón FJ, Sáez-Díaz A, Argüelles-Arias F. Real-world effectiveness and safety of risankizumab in multirefractory Crohn’s disease: A multicenter AIRIS-Crohn registry analysis. World J Gastroenterol 2026; 32(42): 119693 [DOI: 10.3748/wjg.119693]

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