Epitranscriptomic regulation of the COX-2/PGE2 axis by hnRNPA2B1 promotes esophageal squamous cell carcinoma progression

doi:10.3748/wjg.121890

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Nov 7, 2026; 32(41): 121890
Published online Nov 7, 2026. doi: 10.3748/wjg.121890

Table 1 The correlation between expression of hnRNPA2B1 and clinicopathologic characteristics of 30 esophageal squamous cell carcinoma patients

Variables	HnRNPA2B1 expression		P¹ value
Variables	High	Low	P¹ value
Age (years)
< 60	11	7	1.000
≥ 60	8	4
Gender
Female	4	3	1.000
Male	15	8
Grade
I	6	9	0.021
II-III	13	2
Tumor size (cm)
< 5	16	6	0.104
≥ 5	3	5
Lymph node metastasis
N0	11	5	0.412
N+	4	4
COX-2 expression
High	18	5	0.004
Low	1	6

¹Fisher’s precision probability test.

COX-2: Cyclooxygenase-2.

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Citation: Lu JQ, Fang XF, Guo XX, Liu M, Lin JH, Zheng HL, Zhong CM, Lin QY, Huang XY, Wang XZ, Tian H, Que JW, Chen FL, Zheng BY. Epitranscriptomic regulation of the COX-2/PGE2 axis by hnRNPA2B1 promotes esophageal squamous cell carcinoma progression. World J Gastroenterol 2026; 32(41): 121890
URL: https://www.wjgnet.com/1007-9327/full/v32/i41/121890.htm
DOI: https://dx.doi.org/10.3748/wjg.121890

Lu JQ, Fang XF, Guo XX, Liu M, Lin JH, Zheng HL, Zhong CM, Lin QY, Huang XY, Wang XZ, Tian H, Que JW, Chen FL, Zheng BY. Epitranscriptomic regulation of the COX-2/PGE2 axis by hnRNPA2B1 promotes esophageal squamous cell carcinoma progression. World J Gastroenterol 2026; 32(41): 121890 [DOI: 10.3748/wjg.121890]

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