Baseline cytokines and programmed death-ligand 1 prognostic value in advanced gastric cancer with sintilimab plus chemotherapy

doi:10.3748/wjg.120447

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 28, 2026; 32(40): 120447
Published online Oct 28, 2026. doi: 10.3748/wjg.120447

Table 4 Single factor Cox proportional hazards regression analysis of progression-free survival and overall survival

Variable	PFS		OS
Variable	HR (95%CI)	P value	HR (95%CI)	P value
Age (per year)	1.03 (1.01-1.05)	0.011	1.01 (0.99-1.03)	0.388
Sex (female vs male)	0.87 (0.56-1.35)	0.526	0.63 (0.37-1.08)	0.092
ECOG PS (1 vs 0)	0.89 (0.56-1.41)	0.623	1.04 (0.59-1.81)	0.899
Tumor site: GEJ vs gastric	1.21 (0.69-2.1)	0.505	0.89 (0.45-1.76)	0.734
Stage: Metastatic vs LA	1.18 (0.62-2.26)	0.607	0.8 (0.4-1.58)	0.516
Chemo: Taxane vs platinum	1.02 (0.65-1.58)	0.945	0.85 (0.51-1.43)	0.538
BMI (per unit)	1.02 (0.95-1.1)	0.543	0.99 (0.91-1.08)	0.832
AFP: Elevated vs normal	0.97 (0.39-2.4)	0.944	0.82 (0.29-2.28)	0.697
CEA: Elevated vs normal	1.16 (0.74-1.81)	0.512	1.14 (0.68-1.92)	0.609
CA199: Elevated vs normal	1.33 (0.85-2.08)	0.207	0.92 (0.55-1.55)	0.761
CA125: Elevated vs normal	0.8 (0.4-1.6)	0.526	1.02 (0.46-2.25)	0.965
CA724: Elevated vs normal	0.99 (0.64-1.55)	0.978	1.09 (0.64-1.84)	0.761
PD-L1: Positive vs negative	0.1 (0.05-0.19)	< 0.001	0.11 (0.05-0.25)	< 0.001
EBV: Positive vs negative	2.26 (1.08-4.75)	0.031	2.8 (1.17-6.69)	0.020
MMR: DMMR vs pMMR	2.49 (0.77-8.06)	0.127	1.93 (0.47-8.03)	0.364
IL-4: High vs low	1.36 (0.87-2.1)	0.174	1.06 (0.63-1.8)	0.814
IL-6: High vs low	8.12 (4.16-15.85)	< 0.001	7.32 (3.46-15.51)	< 0.001
IL-8: High vs low	1.14 (0.73-1.79)	0.555	1.55 (0.9-2.66)	0.112
IL-10: High vs low	10 (5.07-19.72)	< 0.001	8.26 (3.95-17.27)	< 0.001
IL-17: High vs low	3.72 (2.19-6.31)	< 0.001	5.8 (3.08-10.92)	< 0.001

PFS: Progression-free survival; OS: Overall survival; IL: Interleukin; ECOG: Eastern Cooperative Oncology Group; PS: Performance status; GEJ: Gastroesophageal junction; LA: Locally advanced; BMI: Body mass index; AFP: Alpha-fetoprotein; CEA: Carcinoembryonic antigen; CA: Carbohydrate antigen; PD-L1: Programmed death-ligand 1; EBV: Epstein-Barr virus; MMR: Mismatch repair; dMMR: Deficient mismatch repair; pMMR: Proficient mismatch repair.

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Citation: Li YC, Pan D, Liu HN, Pei ZC, Li YQ, Han ZX, Liu WL. Baseline cytokines and programmed death-ligand 1 prognostic value in advanced gastric cancer with sintilimab plus chemotherapy. World J Gastroenterol 2026; 32(40): 120447
URL: https://www.wjgnet.com/1007-9327/full/v32/i40/120447.htm
DOI: https://dx.doi.org/10.3748/wjg.120447

Li YC, Pan D, Liu HN, Pei ZC, Li YQ, Han ZX, Liu WL. Baseline cytokines and programmed death-ligand 1 prognostic value in advanced gastric cancer with sintilimab plus chemotherapy. World J Gastroenterol 2026; 32(40): 120447 [DOI: 10.3748/wjg.120447]

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