Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study

doi:10.3748/wjg.119619

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 28, 2026; 32(40): 119619
Published online Oct 28, 2026. doi: 10.3748/wjg.119619

Table 5 Performance of biomarkers in predicting acute pancreatitis severity

Parameter	AUC (95%CI)	Cut-off	Se (%)	Sp (%)	PPV (%)	NPV (%)	LR+	LR-	DOR	P value
TAP after 48 hours (pg/mL)	0.692 (0.542-0.842)	25.412	83.3	54.3	32.3	92.6	1.825	0.307	5.945	0.012
TAP after 72 hours (pg/mL)	0.810 (0.692-0.928)	43.844	83.3	73.9	45.5	94.4	3.194	0.225	14.196	< 0.001
CRP after 48 hours (mg/L)	0.794 (0.642-0.946)	21.900	75.0	79.6	47.4	92.9	3.675	0.314	11.704	< 0.001
CRP after 72 hours (mg/L)	0.857 (0.717-0.998)	60.890	75.0	89.8	64.3	93.6	7.350	0.278	26.439	< 0.001

P < 0.05 is statistically significant. AUC: Area under the curve; CRP: C-reactive protein; DOR: Diagnostic odds ratio; LR: Likelihood ratio; NPV: Negative predictive value; PPV: Positive predictive value; Se: Sensitivity; Sp: Specificity; TAP: Trypsinogen activation peptide.

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Citation: Kwiatek-Średzińska KA, Trochimczyk K, Jamiołkowski J, Lebensztejn DM. Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study. World J Gastroenterol 2026; 32(40): 119619
URL: https://www.wjgnet.com/1007-9327/full/v32/i40/119619.htm
DOI: https://dx.doi.org/10.3748/wjg.119619

Kwiatek-Średzińska KA, Trochimczyk K, Jamiołkowski J, Lebensztejn DM. Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study. World J Gastroenterol 2026; 32(40): 119619 [DOI: 10.3748/wjg.119619]

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