Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study

Table 4 Biomarkers in mild and moderately severe acute pancreatitis, mean ± SD

Parameter	Mild AP (n = 49)	Moderately severe AP (n = 12)	P value
Trypsinogen-1 within 24 hours (ng/mL)	0.86 ± 0.75	1.09 ± 1.00	0.973
Trypsinogen-1 after 48 hours (ng/mL)	0.85 ± 0.51	0.89 ± 0.85	0.484
Trypsinogen-1 after 72 hours (ng/mL)	0.82 ± 0.52	0.66 ± 0.35	0.411
Trypsinogen-2 within 24 hours (ng/mL)	0.52 ± 0.95	0.43 ± 0.15	0.256
Trypsinogen-2 after 48 hours (ng/mL)	0.70 ± 1.33	0.44 ± 0.28	0.803
Trypsinogen-2 after 72 hours (ng/mL)	0.37 ± 0.18	0.41 ± 0.24	0.632
TAP within 24 hours (pg/mL)	55.27 ± 52.30	42.25 ± 25.42	0.608
TAP after 48 hours (pg/mL)	37.84 ± 35.60	58.94 ± 51.11	0.043
TAP after 72 hours (pg/mL)	37.11 ± 26.81	64.58 ± 23.76	0.001
CRP at admission (mg/L)	12.41 ± 25.37	25.45 ± 50.61	0.468
CRP after 48 hours (mg/L)	16.54 ± 25.06	65.84 ± 54.73	0.002
CRP after 72 hours (mg/L)	18.53 ± 23.99	105.90 ± 83.61	< 0.001

P < 0.05 is statistically significant. AP: Acute pancreatitis; CRP: C-reactive protein; TAP: Trypsinogen activation peptide.