Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study

doi:10.3748/wjg.119619

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 28, 2026; 32(40): 119619
Published online Oct 28, 2026. doi: 10.3748/wjg.119619

Table 2 Performance of urinary trypsinogen-2 after 48 hours in acute pancreatitis

Parameter	AUC (95%CI)	Cut-off	Se (%)	Sp (%)	PPV (%)	NPV (%)	LR+	LR-	DOR	P value
Trypsinogen-2 after 48 hours (ng/mL)	0.651 (0.535-0.767)	0.381	48.3	82.8	84.8	44.4	2.8	0.625	4.48	0.010

P < 0.05 is statistically significant. AUC: Area under the curve; DOR: Diagnostic odds ratio; LR: Likelihood ratio; NPV: Negative predictive value; PPV: Positive predictive value; Se: Sensitivity; Sp: Specificity.

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Citation: Kwiatek-Średzińska KA, Trochimczyk K, Jamiołkowski J, Lebensztejn DM. Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study. World J Gastroenterol 2026; 32(40): 119619
URL: https://www.wjgnet.com/1007-9327/full/v32/i40/119619.htm
DOI: https://dx.doi.org/10.3748/wjg.119619

Kwiatek-Średzińska KA, Trochimczyk K, Jamiołkowski J, Lebensztejn DM. Urinary trypsinogens and trypsinogen activation peptide as biomarkers in pediatric acute pancreatitis: A prospective observational study. World J Gastroenterol 2026; 32(40): 119619 [DOI: 10.3748/wjg.119619]

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