ARPC1B contributes to colorectal cancer progression and is associated with programmed death-ligand 1 expression

Figure 1 ARPC1B is highly-expressed in colorectal cancer patients. A: The relative messenger RNA (mRNA) expression level of ARPC1B in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) datasets of The Cancer Genome Atlas database. The red boxplot indicates the colorectal cancer (CRC) tumor, and grey boxplot indicates the normal samples; B: The immunohistochemistry results of ARPC1B in CRC tissue and normal tissue were obtained from The Human Protein Atlas database (https://www.proteinatlas.org); C: The relative protein expression level of ARPC1B and programmed death-ligand 1 in 5 pairs of CRC and paracancerous tissue was determined via western blot; D: The statistical analysis of western blot; E: The overall survival of ARPC1B expression in READ by Gene Set Cancer Analysis (GSCA) database; F: The disease-specific survival of ARPC1B expression in READ by GSCA database; G: Spearman correlation between ARPC1B copy number variation (CNV) and mRNA expression in COAD by GSCA database; H: Spearman correlation between ARPC1B CNV and mRNA expression in READ by GSAV database. ^aP < 0.05. ^bP < 0.01. COAD: Colon adenocarcinoma; READ: Rectum adenocarcinoma; CRC: Colorectal cancer; PD-L1: Programmed death-ligand 1; NC: Negative control; OS: Overall survival; DSS: Disease-specific survival; CNV: Copy number variation; mRNA: Messenger RNA; FDR: False discovery rate; RSEM: RNA-sequencing by expectation-maximization.