Synergistic anti-hepatoma effect of triptolide and quercetin via co-inhibition and interaction with Janus kinase and mammalian target of rapamycin signal pathway

Figure 10  Molecular docking analysis of the two molecules with targets. A: Quercetin and triptolide (TP) docked with Janus kinase 1; B: Quercetin and TP docked with signal transducer and activator of transcription 3; C: Quercetin and TP docked with phosphoinositide 3-kinase; D: Quercetin and TP docked with mammalian target of rapamycin. Jak1: Janus kinase 1; Stat3: Signal transducer and activator of transcription 3; PI3K: Phosphoinositide 3-kinase; mTOR: Mammalian target of rapamycin.