Synergistic anti-hepatoma effect of triptolide and quercetin via co-inhibition and interaction with Janus kinase and mammalian target of rapamycin signal pathway

doi:10.3748/wjg.v32.i4.114420

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2026; 32(4): 114420
Published online Jan 28, 2026. doi: 10.3748/wjg.v32.i4.114420

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Figure 9 Pathway functional analysis by Kyoto Encyclopedia of Genes and Genomes compared with control group based on RNA sequencing. A: The top ten signaling pathways with the greatest statistical difference for control group compared with quercetin; B: The top ten signaling pathways with the greatest statistical difference for control group compared with triptolide; C: The top ten signaling pathways with the greatest statistical difference for control group compared with triptolide + quercetin; D: The Venn diagram of signaling pathways for three different drug interventions groups compared with control group. TP: Triptolide; QU: Quercetin.

Citation: Tong HX, Zhang JL, Nie WY, Jiang LJ, Hu JQ, Lu T. Synergistic anti-hepatoma effect of triptolide and quercetin via co-inhibition and interaction with Janus kinase and mammalian target of rapamycin signal pathway. World J Gastroenterol 2026; 32(4): 114420
URL: https://www.wjgnet.com/1007-9327/full/v32/i4/114420.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i4.114420

Tong HX, Zhang JL, Nie WY, Jiang LJ, Hu JQ, Lu T. Synergistic anti-hepatoma effect of triptolide and quercetin via co-inhibition and interaction with Janus kinase and mammalian target of rapamycin signal pathway. World J Gastroenterol 2026; 32(4): 114420 [PMID: 41640866 DOI: 10.3748/wjg.v32.i4.114420]

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