Allyl isothiocyanate ameliorates metabolic dysfunction-associated steatotic liver disease via vitamin D receptors in hepatocytes

Figure 6 Model by which allyl isothiocyanate alleviates metabolic dysfunction-associated steatotic liver disease. Allyl isothiocyanate activates vitamin D receptor to activate the hepatocyte nuclear factor 4 alpha/microsomal triglyceride transfer protein/apolipoprotein B signaling pathway, inhibits lipogenesis, promotes fatty acid β-oxidation, and improves insulin resistance, alleviating metabolic dysfunction-associated steatotic liver disease. AITC: Allyl isothiocyanate; HNF-4α: Hepatocyte nuclear factor 4 alpha; FA: Fatty acid; VDR: Vitamin D receptor; MTTP: Microsomal triglyceride transfer protein; ApoB: Apolipoprotein B.