Comparative efficacy and pharmacological heterogeneity of individual potassium-competitive acid blockers: A systematic review and network meta-analysis

Figure 1 Preferred Reporting Items for Systematic reviews and Meta-Analyses flow diagram illustrating the study selection process. The systematic literature search identified 2441 records from four databases (PubMed: n = 111, EMBASE: n = 1107, Cochrane Library: n = 703, Web of Science: n = 520). After removing 1291 duplicates, 1150 unique records were screened by title and abstract. Following full-text review of 445 articles, 405 were excluded (narrative reviews: n = 6, incomplete data: n = 231, study protocols: n = 11, systematic reviews/guidelines: n = 157). Finally, 40 randomized controlled trials were included: (1) 30 studies for Helicobacter pylori eradication; and (2) 10 studies for erosive esophagitis healing.