Gut microbial metabolites as key mediators in inflammatory bowel disease

Figure 7 Heatmap of the changes in metabolite concentration in the blood serum of all studied groups of mice. A: Hydroxycarboxylic acids; B: Long-chain fatty acids; C: Amino acids and their derivatives; D: Other metabolites. Red indicates an increase in metabolite concentration in the blood; green indicates a decrease. The metabolomic assay was performed in one experiment, consisted of 4 mice per group. ^aP < 0.05 between Muc2^-/- mice vs the control (C57BL/6 mice), Mann-Whitney U test; ^bP < 0.05 between Muc2^-/- mice treated with metabolites vs the control (Muc2^-/- mice without treatment), ^cP < 0.01 between Muc2^-/- mice treated with metabolites vs the control (Muc2^-/- mice without treatment), ^dP < 0.05 between Muc2^-/- mice treated with butyric, propionic and valeric acids vs Muc2^-/- mice treated with butyric, propionic and valeric acids combination, Kruskal-Wallis test with post hoc Dunn’s test, corrected with Benjamini-Hochberg procedure. But: Butyric acid; Prop: Propionic acid; Val: Valeric acid; BPV: Combination of butyric, propionic and valeric acids.