Gut microbial metabolites as key mediators in inflammatory bowel disease

Figure 6 The abundance of the main bacterial phyla in all studied groups of mice. A: Sum of the median level of reads for each phylum presented as cumulative bar chart; B: Abundance of the main bacterial families, genus and species in Bacillota phylum presented as heat map; C: Abundance of the main bacterial families, genus and species in Bacteroidota phylum presented as heat map; D: Abundance of the main bacterial genus and species in Actinomycetota phylum (pink underline), Verrucomicrobiota phylum (black underline), Thermodesulfobacteriota phylum (orange underline), Pseudomonadota phylum (yellow underline) presented as heat map. Values out of range are marked in dark blue color: 20% abundance for Lachnospiraceae family, 12% abundance for Muribaculaceae family, 10% abundance for Akkermansia genus. The metagenomic assay was performed in a single experiment with 4 mice per group. ^aP < 0.05 between Muc2^-/- mice vs the control (C57BL/6 mice), Mann-Whitney U test; ^bP < 0.05 between Muc2^-/- mice treated with metabolites vs the control (Muc2^-/- mice without treatment), ^cP < 0.01 between Muc2^-/- mice treated with metabolites vs the control (Muc2^-/- mice without treatment), Kruskal-Wallis test with post hoc Dunn’s test, corrected with Benjamini-Hochberg procedure. But: Butyric acid; Prop: Propionic acid; Val: Valeric acid.