New insights into the pathogenic variation landscape in pediatric gastroenterology diseases

Table 4 Genetic analysis of patients with pancreatitis in the study of Alsarhan et al[3] and six similar articles published between January 1, 2021, and December 31, 2025

Genes	PRSS1	CTRC	CFTR	SPINK1	Chymotrypsin C	Cathepsin B	CaSR
Ethnics	United Arab Emirates1, Indians2, Italians3	United Arab Emirates4	Japanese5, Americans6, Italians7	Indians8, Italians9, Brazilians10	Indians11	Indians12	Italians13
Ref.	Alsarhan et al[3]; Prakash et al[15]; Destro et al[18]	Alsarhan et al[3]	Fujita et al[13]; Son et al[14]; Bontempo et al[16]	Prakash et al[15]; Bontempo et al[16]; Solis-Pazmino et al[17]	Prakash et al[15]	Prakash et al[15]	Bontempo et al[16]

¹p.Arg122His.

²p.Arg122His.

³p.Asn29Ile.

⁴p.Lys247-Arg254del.

⁵Three heterozygous mutations (p.Thr1220Ile, p.Arg1453Trp, and p.Val470Met).

⁶Heterozygous mutation (p.Asn1303 Lys).

⁷p.Leu997Phe.

⁸p.Asn34Ser.

⁹p.Ile73Phe.

¹⁰p.Asn34Ser.

¹¹p.Ala16Val.

¹²p.Asp22Gly.

¹³p.Phe790Ser.