Genetically influenced pediatric chronic pancreatitis: Radiologic perspectives

Table 2 Clinical and radiological characteristics of patients according to gene groups

Variables		CFTR		CTRC/PRSS1		SPINK1		P value
		n	%	n	%	n	%
Sex	M	6	66.7	2	40.0	2	50.0	0.610
	F	3	33.3	3	60.0	2	50.0
Variant	LP	3	27.3	1	9.1	2	18.2	0.428
	P	1	9.1	0	0.0	1	9.1
	VUS	3	27.3	1	9.1	0	0.0
Imaging findings: MRI/CT
Pancreatic atrophy	Yes	8	88.9	4	80.0	2	50.0	0.311
	No	1	11.1	1	20.0	2	50.0
Acute pancreatitis	Yes	1	11.1	1	20.0	0	0.0	0.667
	No	8	88.9	4	80.0	4	100.0
Dilatation of the CBD	Yes	0	0.0	1	20.0	0	0.0	0.273
	No	9	100.0	4	80.0	4	100.0
Dilatation of the MPD	Yes	4	44.4	3	60.0	1	25.0	0.587
	No	5	55.6	2	40.0	3	75.0
Acute necrotic collections	Yes	1	11.1	0	0.0	0	0.0	0.611
	No	8	88.9	5	100.0	4	100.0
Multifocal pancreatic calcifications	Yes	1	11.1	0	0.0	1	25.0	0.638
	No	8	88.9	5	100.0	3	75.0

P values were calculated using Fisher’s exact test for two-category comparisons and the Fisher-Freeman-Halton exact test for multi-category comparisons. M: Male; F: Female; P: Pathogenic; LP: Likely pathogenic; VUS: Variant of uncertain significance; MRI: Magnetic resonance imaging; CT: Computed tomography; CBD: Common bile duct; MPD: Main pancreatic duct.