Single-cell and bulk transcriptomics with machine learning decode B cell hub genes and diagnostic biomarkers in anal fistula

Figure 9 CellChat analysis of LINC-PINT⁺ B cells in anal fistula. A: CellChat network plots illustrating the number and strength of intercellular communications among different cell types. LINC-PINT⁺ B cells exhibited more extensive and stronger interactions than LINC-PINT-B cells; B: Scatter plot of outgoing vs incoming signaling strength across all cell types. LINC-PINT⁺ B cells show higher overall communication strength; C: Heatmaps of outgoing and incoming signaling patterns across cell types. LINC-PINT⁺ B cells are highly active in classical immune-related pathways; D: The ligand-receptor interactions between different cell types and LRBA^+/- B cells.