Single-cell and bulk transcriptomics with machine learning decode B cell hub genes and diagnostic biomarkers in anal fistula

doi:10.3748/wjg.121425

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 14, 2026; 32(38): 121425
Published online Oct 14, 2026. doi: 10.3748/wjg.121425

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Figure 4 Functional enrichment analysis of candidate genes in anal fistula-related B cells. A: Venn diagram showing the intersection of genes identified from hdWGCNA and differentially expressed genes in B cells, resulting in 129 overlapping genes; B: Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of the 129 overlapping genes; C: Gene Ontology (GO)-biological process enrichment analysis; D: GO-molecular function enrichment analyses; E: GO-cellular component enrichment analysis. hdWGCNA: High-dimensional weighted gene co-expression network analysis.

Citation: Li TT, Li JN, Yang HW, Dou XY, Jiang L, Lai LX, Yu Q, Chen XY, Wang Y, Zhang XC, Ma HF, Song XB. Single-cell and bulk transcriptomics with machine learning decode B cell hub genes and diagnostic biomarkers in anal fistula. World J Gastroenterol 2026; 32(38): 121425
URL: https://www.wjgnet.com/1007-9327/full/v32/i38/121425.htm
DOI: https://dx.doi.org/10.3748/wjg.121425

Li TT, Li JN, Yang HW, Dou XY, Jiang L, Lai LX, Yu Q, Chen XY, Wang Y, Zhang XC, Ma HF, Song XB. Single-cell and bulk transcriptomics with machine learning decode B cell hub genes and diagnostic biomarkers in anal fistula. World J Gastroenterol 2026; 32(38): 121425 [DOI: 10.3748/wjg.121425]

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