Long-term comparative effectiveness of first-line infliximab vs corticosteroids in ulcerative colitis: Remission and colectomy risk

Table 3 Multivariable Cox regression analysis of independent predictors of colectomy in patients with moderate-to-severe ulcerative colitis

Predictors	B	P value	Exp(B)	95%CI for Exp(B)
CRP	0.05	0.040a	1.05	1.01-1.14
Albumin	-0.25	0.035a	0.78	0.13-0.93
Fecal calprotectin	0.37	0.003b	1.45	1.11-4.01
Severity (severe UC)	0.71	0.042a	2.04	1.24-4.46
Extensive colitis	0.17	0.134	1.18	0.17-3.16
CMV infection	1.77	< 0.001b	5.86	1.09-12.53
C. difficile infection	0.52	0.018a	1.68	1.22-5.48
Treatment group (IFX vs IVCS)	-0.64	0.043a	0.53	0.20-0.88

^aP < 0.05.

^bP < 0.01.

B: Regression coefficients, Exp(B): Hazard ratio. Hazard ratios < 1 indicate a reduced risk of colectomy. C. difficile: Clostridioides difficile; CRP: C-reactive protein; UC: Ulcerative colitis; CMV: Cytomegalovirus; IVCS: Intravenous corticosteroids; IFX: Infliximab.