Portulaca oleracea L.-derived exosome-like nanoparticles ameliorate colitis by modulating gut microbiota and metabolites to reduce endoplasmic reticulum stress

doi:10.3748/wjg.120885

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 7, 2026; 32(37): 120885
Published online Oct 7, 2026. doi: 10.3748/wjg.120885

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Figure 10 Schematic illustration: The mechanism of action for orally delivered Portulaca oleracea L. -derived exosome-like nanoparticle in the mitigation of ulcerative colitis. Portulaca oleracea L.-derived exosome-like nanoparticles exert therapeutic benefits through the modulation of the intestinal microbial community and its associated metabolites, alleviating endoplasmic reticulum stress in colitis mice, reducing inflammation, and restoring tight junction integrity in intestinal epithelial cells. ERS: Endoplasmic reticulum stress; PELNs: Portulaca oleracea L.-derived exosome-like nanoparticles.

Citation: Liu XY, Liu ZX, Tan WW, Zhang WB, Qiao D, Chen SH, Zhang YL, Zheng L, Ge WS, Dai YC. Portulaca oleracea L.-derived exosome-like nanoparticles ameliorate colitis by modulating gut microbiota and metabolites to reduce endoplasmic reticulum stress. World J Gastroenterol 2026; 32(37): 120885
URL: https://www.wjgnet.com/1007-9327/full/v32/i37/120885.htm
DOI: https://dx.doi.org/10.3748/wjg.120885

Liu XY, Liu ZX, Tan WW, Zhang WB, Qiao D, Chen SH, Zhang YL, Zheng L, Ge WS, Dai YC. Portulaca oleracea L.-derived exosome-like nanoparticles ameliorate colitis by modulating gut microbiota and metabolites to reduce endoplasmic reticulum stress. World J Gastroenterol 2026; 32(37): 120885 [DOI: 10.3748/wjg.120885]

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