Efficacy of 7-day and 14-day potassium-competitive acid blocker-based bismuth-containing quadruple regimen for Helicobacter pylori infection

doi:10.3748/wjg.119668

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Oct 7, 2026; 32(37): 119668
Published online Oct 7, 2026. doi: 10.3748/wjg.119668

Table 1 Baseline characteristics of the participants (intention-to-treat set), n (%)

Characteristic	7-day PC-BMT (n = 119)	14-day PC-BMT (n = 118)	14-day P-BMT (n = 117)	P value
Sex (male)	68 (57.1)	61 (51.7)	57 (48.7)	0.421
Age (years), median (IQR)	58.0 (13.0)	61.0 (16.0)	60.0 (13.0)	0.271
Body mass index (kg/m²), median (IQR)	24.5 (4.5)	23.5 (3.6)	23.6 (4.8)	0.387
Alcohol	50 (42.0)	40 (33.9)	54 (46.2)	0.150
Smoking	16 (13.5)	24 (20.3)	19 (16.2)	0.359
Endoscopic findings
Chronic atrophic gastritis	93 (78.2)	88 (74.6)	90 (76.9)	0.805
H. pylori-induced gastritis	17 (14.3)	21 (17.8)	14 (12.0)	0.446
Gastric ulcer				0.780
A1-H2	7 (5.9)	7 (5.9)	4 (3.4)
S1-S2	9 (7.6)	6 (5.1)	9 (7.7)
Duodenal ulcer				0.509
A1-H2	2 (1.7)	4 (3.4)	2 (1.7)
S1-S2	6 (5.2)	8 (7.0)	12 (10.4)
Endoscopic resection of early gastric cancer or gastric adenoma	4 (3.4)	7 (5.9)	8 (6.8)	0.469
Mucosa-associated lymphoid tissue lymphoma	0 (0.0)	0 (0.0)	2 (1.7)	0.109
Antibiotic resistance of H. pylori
Cultured	66 (55.5)	67 (56.8)	62 (53.0)	0.839
Single resistance	20 (30.3)	33 (49.3)	26 (41.9)	0.081
Clarithromycin resistance	10 (15.2)	14 (20.9)	8 (12.9)	0.446
Amoxicillin resistance	1 (1.5)	3 (4.5)	2 (3.2)	0.694
Metronidazole resistance	9 (13.6)	15 (22.4)	16 (25.8)	0.210
Tetracycline resistance	0 (0.0)	1 (1.5)	0 (0.0)	> 0.999
Dual resistance	8 (12.1)	6 (9.0)	7 (11.3)	0.830
Clarithromycin and amoxicillin	8 (12.1)	4 (6.0)	6 (9.7)	0.467
Clarithromycin and metronidazole	0 (0.0)	2 (3.0)	1 (1.6)	0.537
Multiple resistance	0 (0.0)	1 (1.5)	0 (0.0)	> 0.999
Compliance (%), median (IQR)	100.0 (0.0)	100.0 (0.0)	100.0 (0.0)	0.671
Poor compliance (< 80%)	3 (2.5)	7 (5.9)	6 (5.1)	0.417

IQR: Interquartile range; H. pylori: Helicobacter pylori; P-BMT: Proton pump inhibitor-based bismuth-containing quadruple regimen; PC-BMT: Potassium-competitive acid blocker-based bismuth-containing quadruple regimen.

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Citation: Oh CK, Lim H, Noh JH, Gong EJ, Seo SI, Bang CS, Kim YJ, Shin WG, Kim JB, Jang HJ, Baik GH. Efficacy of 7-day and 14-day potassium-competitive acid blocker-based bismuth-containing quadruple regimen for Helicobacter pylori infection. World J Gastroenterol 2026; 32(37): 119668
URL: https://www.wjgnet.com/1007-9327/full/v32/i37/119668.htm
DOI: https://dx.doi.org/10.3748/wjg.119668

Oh CK, Lim H, Noh JH, Gong EJ, Seo SI, Bang CS, Kim YJ, Shin WG, Kim JB, Jang HJ, Baik GH. Efficacy of 7-day and 14-day potassium-competitive acid blocker-based bismuth-containing quadruple regimen for Helicobacter pylori infection. World J Gastroenterol 2026; 32(37): 119668 [DOI: 10.3748/wjg.119668]

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