Low-dose vs standard-dose minocycline in bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized controlled, noninferiority trial

doi:10.3748/wjg.122851

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 28, 2026; 32(36): 122851
Published online Sep 28, 2026. doi: 10.3748/wjg.122851

Table 2 Helicobacter pylori eradication rate between the two groups, % (n/total)

Regimens	Low-dose group	Standard-dose group	P value (difference)	P value (noninferiority)	95%CI
ITT analysis	84.2 (101/120)	87.5 (105/120)	0.459	0.069	-10.7% to 4.1%
PP analysis	91.0 (101/111)	92.9 (105/113)	0.595	0.013^a	-7.9% to 4.1%

^aP < 0.05.

ITT: Intention-to-treat; PP: Per-protocol.

Full Size Table

Citation: Zhu YN, Wang YB, Li L, Ren YD, Wang RR, Ji YL, Wang YP, Zhai HY, Jiang Y. Low-dose vs standard-dose minocycline in bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized controlled, noninferiority trial. World J Gastroenterol 2026; 32(36): 122851
URL: https://www.wjgnet.com/1007-9327/full/v32/i36/122851.htm
DOI: https://dx.doi.org/10.3748/wjg.122851

Zhu YN, Wang YB, Li L, Ren YD, Wang RR, Ji YL, Wang YP, Zhai HY, Jiang Y. Low-dose vs standard-dose minocycline in bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized controlled, noninferiority trial. World J Gastroenterol 2026; 32(36): 122851 [DOI: 10.3748/wjg.122851]

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