Low-dose vs standard-dose minocycline in bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized controlled, noninferiority trial

doi:10.3748/wjg.122851

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 28, 2026; 32(36): 122851
Published online Sep 28, 2026. doi: 10.3748/wjg.122851

Table 1 Demographic and clinical data of all patients, n (%)

Variables	Low-dose group (n = 120)	Standard-dose group (n = 120)	P value
Male sex	63 (52.5)	58 (48.3)	0.519
Age (year), mean ± SD	65.4 ± 4.4	66.3 ± 5.0	0.137
Smoking	64 (53.3)	59 (49.2)	0.518
Alcohol	62 (51.7)	60 (50.0)	0.796
Coronary artery disease	56 (46.7)	57 (47.5)	0.897
Diabetes	61 (50.8)	62 (51.7)	0.897
Hypertension	53 (44.2)	54 (45.0)	0.897
Use of NSAIDs	34 (28.3)	30 (25.0)	0.559
BMI (kg/m²), mean ± SD	22.9 ± 2.9	23.5 ± 4.0	0.16
Concomitant peptic ulcers
Gastric ulcer	10	11	0.951
Duodenal ulcer	15	16

BMI: Body mass index; NSAID: Nonsteroidal anti-inflammatory drug.

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Citation: Zhu YN, Wang YB, Li L, Ren YD, Wang RR, Ji YL, Wang YP, Zhai HY, Jiang Y. Low-dose vs standard-dose minocycline in bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized controlled, noninferiority trial. World J Gastroenterol 2026; 32(36): 122851
URL: https://www.wjgnet.com/1007-9327/full/v32/i36/122851.htm
DOI: https://dx.doi.org/10.3748/wjg.122851

Zhu YN, Wang YB, Li L, Ren YD, Wang RR, Ji YL, Wang YP, Zhai HY, Jiang Y. Low-dose vs standard-dose minocycline in bismuth quadruple therapy for first-line Helicobacter pylori eradication: A randomized controlled, noninferiority trial. World J Gastroenterol 2026; 32(36): 122851 [DOI: 10.3748/wjg.122851]

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