AKT-eNOS-NO pathway mediates spontaneous portosystemic shunts and therapeutic efficacy of SC79 in cirrhosis

Figure 7 SC79 treatment ameliorates cirrhosis and reduces spontaneous portosystemic shunts in vivo. A: Incidence of spontaneous portosystemic shunts in sham, cirrhosis, and SC79-treated groups; B: Serum albumin; C: Ascites incidence; D: Representative liver histology by hematoxylin and eosin, Masson, and Sirius red staining; E: Quantification of Masson staining; F: Quantification of Sirius red staining; G: Expression of AKT, p-AKT, eNOS, and p-eNOS; H: Hepatic nitric oxide levels. Data are showed as mean ± SD (n = 5 per group). ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NS: Not significant; H&E: Hematoxylin and eosin; NO: Nitric oxide.