AKT-eNOS-NO pathway mediates spontaneous portosystemic shunts and therapeutic efficacy of SC79 in cirrhosis

doi:10.3748/wjg.119990

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 28, 2026; 32(36): 119990
Published online Sep 28, 2026. doi: 10.3748/wjg.119990

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Figure 4 Integrated proteomic and metabolomic analysis highlights key pathways in spontaneous portosystemic shunts. A: Venn diagram of common Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enriched in both proteomics and metabolomics; B: Bubble plot of common KEGG pathways enriched in both proteomics and metabolomics; C: Enrichment analysis of the cGMP-PKG pathway; D: Immunohistochemical staining of AKT and p-AKT in liver tissues; E: Quantification of AKT staining; F: Quantification of p-AKT staining. Data are presented as mean ± SD (n = 5 per group). ^aP < 0.05. NO: Nitric oxide; SPSS: Spontaneous portosystemic shunts.

Citation: Ke Q, Guo ZT, He J, Huang XH, Lei XJ, Zhuang QY, Zhou Y, Li L, Wang YC, Liu JF, Guo WH. AKT-eNOS-NO pathway mediates spontaneous portosystemic shunts and therapeutic efficacy of SC79 in cirrhosis. World J Gastroenterol 2026; 32(36): 119990
URL: https://www.wjgnet.com/1007-9327/full/v32/i36/119990.htm
DOI: https://dx.doi.org/10.3748/wjg.119990

Ke Q, Guo ZT, He J, Huang XH, Lei XJ, Zhuang QY, Zhou Y, Li L, Wang YC, Liu JF, Guo WH. AKT-eNOS-NO pathway mediates spontaneous portosystemic shunts and therapeutic efficacy of SC79 in cirrhosis. World J Gastroenterol 2026; 32(36): 119990 [DOI: 10.3748/wjg.119990]

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