Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea

doi:10.3748/wjg.119724

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 28, 2026; 32(36): 119724
Published online Sep 28, 2026. doi: 10.3748/wjg.119724

Table 3 Comparison based on lesion size increase (≥ 10 mm), n (%)

		Increased (n = 44)	Not increased (n = 2502)	P value
Sex	Male	17 (38.6)	1145 (45.8)	0.347
	Female	27 (61.4)	1357 (54.2)
Age at diagnosis (mean ± SD)		61.86 ± 12.54	66.13 ± 13.32	0.031
Duration of F/U (mean ± SD, month)		89.79 ± 45.92	79.18 ± 46.45	0.136
Size (mean ± SD)		11.32 ± 9.42	8.55 ± 5.80	0.059
Size group	< 1 cm	19 (43.2)	1581 (63.2)	< 0.001
	1-2 cm	19 (43.2)	738 (29.5)
	2-3 cm	2 (4.5)	145 (5.8)
	≥ 3 cm	4 (9.1)	38 (1.5)
Shape	Round	26 (72.2)	1986 (91.8)	< 0.001
	Irregular	10 (27.8)	178 (8.2)
Ulceration	Absent	44 (100.0)	2495 (99.8)	0.767
	Present	0 (0.0)	5 (0.2)
Erosion	Absent	44 (100.0)	2480 (99.2)	0.551
	Present	0 (0.0)	20 (0.8)
Rolling sign	Absent	22 (71.0)	746 (42.7)	0.002
	Present	9 (29.0)	1001 (57.3)
Cushion sign	Absent	27 (87.1)	1586 (85.7)	0.829
	Present	4 (12.9)	264 (14.3)
Originating layer	Mucosa	2 (7.4)	135 (16.0)	0.474
	Submucosa	8 (29.6)	215 (25.5)
	Proper muscle	17 (63.0)	493 (58.5)
Echogenicity	Hypoechoic	27 (100.0)	776 (91.5)	0.287
	Isoechoic	0 (0.0)	22 (2.6)
	Hyperechoic	0 (0.0)	50 (5.9)
Homogeneity	Homogenous	12 (44.4)	633 (75.1)	< 0.001
	Heterogenous	15 (55.6)	210 (24.9)
Internal change	None	20 (74.1)	608 (74.2)	0.650
	Anechoic space	1 (3.7)	70 (8.5)
	Calcification	1 (3.7)	41 (5.0)
	Echogenic foci	5 (18.5)	90 (11.0)
	Septation	0 (0.0)	10 (1.2)

F/U: Follow-up.

Full Size Table

Citation: Choi Y, Park JY, Kim SE, Park JM, Kim JS, Chung H, Kim SH, Park CH, Kim SH, Park SY, Lee BE, Lee SW, Lee A, Lee JH, Jung DH, Jo HH, Yoo IH, Min BH, Jung HY. Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea. World J Gastroenterol 2026; 32(36): 119724
URL: https://www.wjgnet.com/1007-9327/full/v32/i36/119724.htm
DOI: https://dx.doi.org/10.3748/wjg.119724

Choi Y, Park JY, Kim SE, Park JM, Kim JS, Chung H, Kim SH, Park CH, Kim SH, Park SY, Lee BE, Lee SW, Lee A, Lee JH, Jung DH, Jo HH, Yoo IH, Min BH, Jung HY. Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea. World J Gastroenterol 2026; 32(36): 119724 [DOI: 10.3748/wjg.119724]

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