Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea

doi:10.3748/wjg.119724

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 28, 2026; 32(36): 119724
Published online Sep 28, 2026. doi: 10.3748/wjg.119724

Table 2 Comparison based on lesion size increase (≥ 5 mm), n (%)

		Increased (n = 145)	Not increased (n = 2401)	P value
Sex	Male	61 (42.1)	1101 (45.9)	0.374
	Female	84 (57.9)	1300 (54.1)
Age at diagnosis (mean ± SD)		62.29 ± 12.45	66.28 ± 13.33	< 0.001
Duration of F/U (mean ± SD, month)		96.05 ± 45.75	78.36 ± 46.31	0.001
Size (mean ± SD)		10.48 ± 7.29	8.49 ± 5.78	< 0.001
Size group	< 1 cm	68 (46.9)	1532 (63.8)	< 0.001
	1-2 cm	55 (37.9)	702 (29.2)
	2-3 cm	18 (12.4)	129 (5.4)
	≥ 3 cm	4 (2.8)	38 (1.6)
Shape	Round	100 (84.7)	1912 (91.8)	0.007
	Irregular	18 (15.3)	170 (8.2)
Ulceration	Absent	145 (100.0)	2394 (99.8)	0.582
	Present	0 (0.0)	5 (0.2)
Erosion	Absent	145 (100.0)	2379 (99.2)	0.270
	Present	0 (0.0)	20 (0.8)
Rolling sign	Absent	70 (66.7)	698 (41.7)	< 0.001
	Present	35 (33.3)	975 (58.3)
Cushion sign	Absent	88 (80.7)	1525 (86.1)	0.123
	Present	21 (19.3)	247 (13.9)
Originating layer	Mucosa	7 (8.4)	130 (16.5)	0.153
	Submucosa	24 (28.9)	199 (25.3)
	Proper muscle	52 (62.7)	458 (58.2)
Echogenicity	Hypoechoic	74 (89.2)	729 (92.0)	0.205
	Isoechoic	1 (1.2)	21 (2.7)
	Hyperechoic	8 (9.6)	42 (5.3)
Homogeneity	Homogenous	50 (60.2)	595 (75.6)	0.002
	Heterogenous	33 (39.8)	192 (24.4)
Internal change	None	59 (70.2)	569 (74.7)	0.439
	Anechoic space	9 (10.7)	62 (8.1)
	Calcification	3 (3.6)	39 (5.1)
	Echogenic foci	13 (15.5)	82 (10.8)
	Septation	0 (0.0)	10 (1.3)

F/U: Follow-up.

Full Size Table

Citation: Choi Y, Park JY, Kim SE, Park JM, Kim JS, Chung H, Kim SH, Park CH, Kim SH, Park SY, Lee BE, Lee SW, Lee A, Lee JH, Jung DH, Jo HH, Yoo IH, Min BH, Jung HY. Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea. World J Gastroenterol 2026; 32(36): 119724
URL: https://www.wjgnet.com/1007-9327/full/v32/i36/119724.htm
DOI: https://dx.doi.org/10.3748/wjg.119724

Choi Y, Park JY, Kim SE, Park JM, Kim JS, Chung H, Kim SH, Park CH, Kim SH, Park SY, Lee BE, Lee SW, Lee A, Lee JH, Jung DH, Jo HH, Yoo IH, Min BH, Jung HY. Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea. World J Gastroenterol 2026; 32(36): 119724 [DOI: 10.3748/wjg.119724]

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