Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea

doi:10.3748/wjg.119724

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 28, 2026; 32(36): 119724
Published online Sep 28, 2026. doi: 10.3748/wjg.119724

Table 1 Comparison based on lesion size increase (≥ 25%), n (%)

		Increased (n = 287)	Not increased (n = 2259)	P value
Sex	Male	119 (41.5)	1043 (46.2)	0.132
	Female	168 (58.5)	1216 (53.8)
Age at diagnosis (mean ± SD)		60.52 ± 13.29	66.76 ± 13.15	< 0.001
Duration of F/U (mean ± SD, month)		91.75 ± 46.89	77.79 ± 46.17	< 0.001
Size (mean ± SD)		7.45 ± 5.50	8.75 ± 5.92	< 0.001
Size group	< 1 cm	205 (71.4)	1395 (61.8)	0.007
	1-2 cm	70 (24.4)	687 (30.4)
	2-3 cm	8 (2.8)	139 (6.2)
	≥ 3 cm	4 (1.4)	38 (1.7)
Shape	Round	198 (89.6)	1814 (91.7)	0.297
	Irregular	23 (10.4)	165 (8.3)
Ulceration	Absent	287 (100.0)	2252 (99.8)	0.425
	Present	0 (0.0)	5 (0.2)
Erosion	Absent	287 (100.0)	2237 (99.1)	0.109
	Present	0 (0.0)	20 (0.9)
Rolling sign	Absent	111 (52.1)	657 (42.0)	0.005
	Present	102 (47.9)	908 (58.0)
Cushion sign	Absent	176 (84.2)	1437 (85.9)	0.499
	Present	33 (15.8)	235 (14.1)
Originating layer	Mucosa	9 (8.0)	128 (16.9)	0.015
	Submucosa	25 (22.1)	198 (26.2)
	Proper muscle	79 (69.9)	431 (56.9)
Echogenicity	Hypoechoic	101 (87.8)	702 (92.4)	0.250
	Isoechoic	4 (3.5)	18 (2.4)
	Hyperechoic	10 (8.7)	40 (5.3)
Homogeneity	Homogenous	75 (67.0)	570 (75.2)	0.063
	Heterogenous	37 (33.0)	188 (24.8)
Internal change	None	92 (80.7)	536 (73.2)	0.421
	Anechoic space	7 (6.1)	64 (8.7)
	Calcification	5 (4.4)	37 (5.1)
	Echogenic foci	10 (8.8)	85 (11.6)
	Septation	0 (0.0)	10 (1.4)

F/U: Follow-up.

Full Size Table

Citation: Choi Y, Park JY, Kim SE, Park JM, Kim JS, Chung H, Kim SH, Park CH, Kim SH, Park SY, Lee BE, Lee SW, Lee A, Lee JH, Jung DH, Jo HH, Yoo IH, Min BH, Jung HY. Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea. World J Gastroenterol 2026; 32(36): 119724
URL: https://www.wjgnet.com/1007-9327/full/v32/i36/119724.htm
DOI: https://dx.doi.org/10.3748/wjg.119724

Choi Y, Park JY, Kim SE, Park JM, Kim JS, Chung H, Kim SH, Park CH, Kim SH, Park SY, Lee BE, Lee SW, Lee A, Lee JH, Jung DH, Jo HH, Yoo IH, Min BH, Jung HY. Natural history of asymptomatic subepithelial lesions of the upper gastrointestinal tract: A multicenter study in Korea. World J Gastroenterol 2026; 32(36): 119724 [DOI: 10.3748/wjg.119724]

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