Association of prealbumin with risk of abdominal surgery and endoscopic recurrence in Crohn’s disease: A machine learning study

Table 4 Association between prealbumin levels and the risks of needing surgery and endoscopic recurrence based on segmented regression analysis

Model	Surgery, HR (95%CI), P value		Model	Recurrence, HR (95%CI), P value
	PA ≤ 208.149 mg/L	PA > 208.149 mg/L		PA ≤ 148.816 mg/L	PA > 148.816 mg/L
Model 11	0.989 (0.986-0.993), < 0.001	0.997 (0.989-1.004), 0.380	Model 44	0.999 (0.993-1.006), 0.849	0.993 (0.987-0.999), 0.035
Model 22	0.989 (0.986-0.993), < 0.001	0.997 (0.989-1.004), 0.383	Model 55	0.999 (0.993-1.005), 0.773	0.992 (0.996-0.999), 0.016
Model 33	0.991 (0.987-0.995), < 0.001	0.997 (0.989-1.005), 0.483	Model 66	1.002 (0.994-1.010), 0.593	0.988 (0.981-0.996), 0.001

¹Model 1 was the crude model.

²Model 2 was adjusted for gender, body mass index, and smoking history.

³Model 3 was further adjusted for gender, body mass index, smoking history, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, C-reactive protein, haemoglobin, erythrocyte sedimentation rate, albumin, prothrombin time, fibrinogen, D-dimer, the Montreal A and B classifications, Crohn’s Disease Activity Index, perianal abscess, and the biological therapy.

⁴Model 4 was the crude model.

⁵Model 5 was adjusted for gender, age, body mass index, and smoking history.

⁶Model 6 was further adjusted for gender, age, body mass index, smoking history, white blood cells, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, albumin, fibrinogen, Crohn’s Disease Activity Index, perianal abscess, and preoperative-biologics.

PA: Prealbumin; HR: Hazard ratio; CI: Confidence interval.