Association of prealbumin with risk of abdominal surgery and endoscopic recurrence in Crohn’s disease: A machine learning study

Table 3 Quantile regression analysis of the association between prealbumin and the risks of needing surgery and endoscopic recurrence

	Q1	Q2, HR (95%CI) P value	Q3, HR (95%CI) P value	Q4, HR (95%CI) P value	P for trend
Surgery
Model 11	Recurrence	0.45 (0.32-0.64), < 0.001	0.33 (0.23-0.48), < 0.001	0.25 (0.17-0.37), < 0.001	< 0.001
Model 22	Recurrence	0.45 (0.32-0.63), < 0.001	0.32 (0.22-0.46), < 0.001	0.24 (0.16-0.35), < 0.001	< 0.001
Model 33	Recurrence	0.50 (0.35-0.73), < 0.001	0.31 (0.20-0.47), < 0.001	0.20 (0.13-0.33), < 0.001	< 0.001
Recurrence
Model 44	Recurrence	0.93 (0.60-1.45), 0.747	0.55 (0.34-0.89), 0.014	0.38 (0.23-0.61), < 0.001	< 0.001
Model 55	Recurrence	0.94 (0.60-1.48), 0.789	0.49 (0.30-0.81), 0.005	0.34 (0.21-0.56), < 0.001	< 0.001
Model 66	Recurrence	1.25 (0.75-2.07), 0.389	0.59 (0.33-1.05), 0.074	0.45 (0.26-0.80), 0.007	< 0.001

¹Model 1 was the crude model.

²Model 2 was adjusted for gender, body mass index, and smoking history.

³Model 3 was further adjusted for gender, body mass index, smoking history, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, C-reactive protein, haemoglobin, erythrocyte sedimentation rate, albumin, prothrombin time, fibrinogen, D-dimer, the Montreal A and B classifications, Crohn’s Disease Activity Index, perianal abscess, and the biological therapy.

⁴Model 4 was the crude model.

⁵Model 5 was adjusted for gender, age, body mass index, and smoking history.

⁶Model 6 was further adjusted for gender, age, body mass index, smoking history, white blood cells, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, albumin, fibrinogen, Crohn’s Disease Activity Index, perianal abscess, and preoperative-biologics.

HR: Hazard ratio; CI: Confidence interval.