Association of prealbumin with risk of abdominal surgery and endoscopic recurrence in Crohn’s disease: A machine learning study

Table 2 Baseline characteristics of the primary Crohn’s disease surgical cohort, n (%)/median (interquartile range)

Characteristics	Total cohort	Q1	Q2	Q3	Q4	P value
	282	71	71	70	70
Demographics
Gender						0.069
Female	62 (22.0)	19 (26.8)	20 (28.2)	15 (21.4)	8 (11.4)
Male	220 (78.0)	52 (73.2)	51 (71.8)	55 (78.6)	62 (88.6)
Smoking						0.977
Yes	93 (33.0)	24 (33.8)	22 (31.0)	24 (34.3)	23 (32.9)
No	189 (67.0)	47 (66.2)	49 (69.0)	46 (65.7)	47 (67.1)
BMI (kg/m2)	17.9 (15.9, 20.1)	17.0 (15.1, 19.1)	17.8 (15.9, 20.4)	18.0 (16.9, 20.4)	17.8 (16.0, 20.1)	0.155
Laboratory tests
WBC (109)	5.86 (4.27, 7.78)	6.40 (4.46, 9.02)	5.29 (4.14, 8.38)	6.19 (4.77, 7.50)	5.40 (4.21, 7.06)	0.173
NLR	3.73 (2.41, 6.10)	5.26 (3.54, 10.2)	3.88 (2.17, 6.60)	3.18 (2.45, 4.68)	3.34 (2.20, 5.07)	< 0.001
LMR	2.65 (1.72, 4.20)	1.81 (1.35, 3.27)	2.36 (1.58, 3.81)	3.11 (2.41, 4.72)	3.31 (2.18, 4.53)	< 0.001
CRP (mg/dL)	2.02 (0.77, 6.76)	3.58 (1.93, 9.13)	2.21 (1.10, 7.52)	1.20 (0.48, 2.68)	1.08 (0.43, 3.05)	< 0.001
Hb (g/dL)	115 (98, 132)	99 (84, 120)	110 (93, 121.5)	126 (113, 135.8)	127.5 (113, 139)	< 0.001
ESR (mm/hour)	21.5 (11, 41)	38 (20.5, 62)	31 (17, 49)	16 (9, 26.5)	12 (7, 27.75)	< 0.001
PA (mg/L)	164.7 (108.7, 217.7)	76.5 (58.8, 96.8)	137.7 (128, 152.8)	194.2 (175.27, 206.8)	247.4 (222.9, 262.3)	< 0.001
ALB (g/dL)	35 (30.1, 39.4)	30.1 (26.5, 36.5)	33.9 (30.4, 37.5)	36.6 (33.5, 40.1)	37.3 (32.8, 41.5)	< 0.001
Fg (g/L)	2.95 (2.79, 3.52)	3.24 (2.86, 3.83)	3.01 (2.81, 3.76)	2.88 (2.74, 3.20)	2.91 (2.71, 3.18)	< 0.001
D-dimer (mg/L)	0.51 (0.26, 1.08)	0.75 (0.35, 1.98)	0.81 (0.41, 1.39)	0.34 (0.20, 0.64)	0.33 (0.21, 0.62)	< 0.001
Crohn’s disease related
Montreal A classification						0.140
1	20 (7.1)	3 (4.2)	3 (4.2)	9 (12.9)	5 (7.1)
2	197 (69.9)	55 (77.5)	49 (69.0)	49 (70.0)	44 (62.9)
3	65 (23.0)	13 (18.3)	19 (26.8)	12 (17.1)	21 (30.0)
Montreal B classification						0.053
1	16 (5.7)	4 (5.6)	7 (9.9)	1 (1.4)	4 (5.7)
2	113 (40.1)	24 (33.8)	21 (29.6)	37 (52.9)	31 (44.3)
3	153 (54.3)	43 (60.6)	43 (60.6)	32 (45.7)	35 (50.0)
Montreal L classification						0.668
1	87 (30.9)	18 (25.4)	20 (28.2)	19 (27.1)	30 (42.9)
2	16 (5.7)	5 (7.0)	4 (5.6)	4 (5.7)	3 (4.3)
3	159 (56.4)	42 (59.2)	42 (59.2)	42 (60.0)	33 (47.1)
4	20 (7.1)	6 (8.5)	5 (7.0)	5 (7.1)	4 (5.7)
CDAI						0.011
Remission	74 (26.2)	9 (12.7)	20 (28.2)	19 (27.1)	26 (37.1)
Active	208 (73.8)	62 (87.3)	51 (71.8)	51 (72.9)	44 (62.9)
Perianal abscess						0.085
No	240 (85.1)	54 (76.1)	61 (85.9)	62 (88.6)	63 (90.0)
Yes	42 (14.9)	17 (23.9)	10 (14.1)	8 (11.4)	7 (10.0)
Preoperative use of drugs
5-aminosalicylic acid	83 (29.4)	20 (28.2)	17 (23.9)	26 (37.1)	20 (28.6)	0.282
Steroid	78 (27.7)	18 (25.4)	16 (22.5)	24 (34.3)	20 (28.6)	0.425
Immunosuppressant	105 (37.2)	24 (33.8)	30 (42.3)	28 (40.0)	23 (32.9)	0.624
Biological agent	103 (36.5)	26 (36.6)	23 (32.4)	25 (35.7)	29 (41.4)	0.737

BMI: Body mass index; WBC: White blood cells; NLR: Neutrophil-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; CRP: C-reactive protein; Hb: Haemoglobin; ESR: Erythrocyte sedimentation rate; PA: Prealbumin; ALB: Albumin; PT: Prothrombin time; Fg: Fibrinogen; CDAI: Crohn’s Disease Activity Index.