Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases

doi:10.3748/wjg.119520

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 28, 2026; 32(36): 119520
Published online Sep 28, 2026. doi: 10.3748/wjg.119520

Table 3 Key unresolved questions and recommended experimental approaches in aging research

Unresolved question	Current limitation	Recommended approach
Which microbial taxa regulate hepatic HADHB	Lack of causal evidence	Germ-free models + microbiota transplantation
Is TMAO causally involved in aging	Mostly associative data	Longitudinal human studies + intervention trials
How does microbiota affect neuroinflammation	Mechanisms unclear	Multi-omics + BBB models
Can TCM effects be linked to microbiota causally	Limited mechanistic studies	Standardized formulations + microbiome sequencing
Are findings aging-specific or disease-driven	Evidence mainly from disease models	Dedicated aging cohorts

HADHB: Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; TMAO: Trimethylamine N-oxide; BBB: Blood-brain barrier; TCM: Traditional Chinese medicine.

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Citation: Hou ZW, Zhang P, Chen C. Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases. World J Gastroenterol 2026; 32(36): 119520
URL: https://www.wjgnet.com/1007-9327/full/v32/i36/119520.htm
DOI: https://dx.doi.org/10.3748/wjg.119520

Hou ZW, Zhang P, Chen C. Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases. World J Gastroenterol 2026; 32(36): 119520 [DOI: 10.3748/wjg.119520]

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