Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases

doi:10.3748/wjg.119520

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2026; 32(36): 119520
Published online Sep 28, 2026. doi: 10.3748/wjg.119520

Table 1 Evidence grading of microbiota–multi-organ axis mechanisms in aging

Mechanism	Description	Evidence level	Evidence type
Gut-brain axis	Microbiota influences BBB and microglia	Strong	Animal + human
TMAO	Associated with cardiovascular risk	Moderate	Cohort + experimental
HADHB pathway	Microbiota-liver FAO link	Limited	Animal
TCM-microbiota	Multi-target modulation	Speculative	Preclinical

BBB: Blood-brain barrier; TMAO: Trimethylamine N-oxide; HADHB: Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; FAO: Fatty acid oxidation; TCM: Traditional Chinese medicine.

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Citation: Hou ZW, Zhang P, Chen C. Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases. World J Gastroenterol 2026; 32(36): 119520
URL: https://www.wjgnet.com/1007-9327/full/v32/i36/119520.htm
DOI: https://dx.doi.org/10.3748/wjg.119520

Hou ZW, Zhang P, Chen C. Gut microbiota-multi-organ axis and neuroinflammatory network: A potential integrative hub in aging and age-related diseases. World J Gastroenterol 2026; 32(36): 119520 [DOI: 10.3748/wjg.119520]

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