Serum anti-enteric neuronal antibodies in patients with achalasia and their association with clinical profiles

Table 1 Correlation of achalasia of cardia clinical profiles and anti-enteric neuronal antibodies status, mean ± SD/n (%)/median interquartile range

Parameter	AENA negative (n = 38)	AENA positive (n = 59)	P value
Demography
Female	17 (44.7)	32 (54.2)	0.480
Age, year	41.6 ± 13.9	46.7 ± 14.2	0.082
Weight, kg	57.0 (50.0 to 65.0)	58.00 (53.0 to 66.0)	0.453
BMI, kg/m2	20.3 (18.3 to 21.4)	21.63 (19.2 to 24.2)	0.051
Disease duration, year	3.6 (2.0 to 9.0)	4.0 (2.5 to 5.0)	0.792
Previous intervention	4 (10.5)	11 (18.6)	0.559
Eckardt scores	7.0 (5.0 to 8.0)	6.0 (5.0 to 8.0)	0.905
CARS scores	4.0 (3.0 to 5.0)	5.0 (3.0 to 5.0)	0.045a
HRM parameters
IRP, mmHg	20.2 ± 10.5	17.2 ± 9.0	0.214
BLESP, mmHg	29.8 (22.1 to 40.0)	30.1 (22.4 to 37.5)	0.714
DCI, mmHg/second/cm	47.0 (2.0 to 160.0)	59.5 (2.0 to 176.0)	0.888
AC subtype			> 0.99
Type I	19 (50.0)	28 (47.5)
Type II	18 (47.4)	29 (49.2)
Barium esophagogram
Barium width, mm	41.5 (36.5 to 49.0)	41.5 (35.0 to 47.0)	0.652
Esophageal distortion			0.503
None	18 (56.3)	23 (42.6)
Mild	6 (18.8)	21 (38.9)
Moderate	6 (18.8)	6 (11.1)
Severe	2 (6.3)	4 (7.4)

^aP < 0.05.

Comparisons were performed using Student’s t-test, Mann-Whitney U test, or χ² test, as appropriate. AENA: Anti-enteric neuronal antibodies; BMI: Body mass index; CARS: Contents, anatomy, resistance, and stasis; HRM: High-resolution manometry; IRP: Integrated relaxation pressure; BLESP: Basal lower esophageal sphincter pressure; AC: Achalasia of cardia; DCI: Distal contractile integral.