Tn antigen-driven downregulation of podoplanin promotes colorectal cancer invasion

doi:10.3748/wjg.121494

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 21, 2026; 32(35): 121494
Published online Sep 21, 2026. doi: 10.3748/wjg.121494

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Figure 4 Overexpression of podoplanin decreases the proliferation and metastatic capabilities of colorectal cancer cells. A and B: Western blot detection of podoplanin (PDPN) overexpression; C: Flow cytometry detection of PDPN overexpression; D: The cell counting kit-8 proliferation assay revealed a significant decrease in the proliferation rate of colorectal cancer (CRC) cells overexpressing PDPN; E and F: The Transwell assay revealed a reduction in the invasion ability of CRC cells overexpressing PDPN. OE: Overexpression; PDPN: Podoplanin.

Citation: Fan LW, Wu XZ, Liu ZW, Lin Q, Du JX, Tian YT, Dong XC, Xu DK. Tn antigen-driven downregulation of podoplanin promotes colorectal cancer invasion. World J Gastroenterol 2026; 32(35): 121494
URL: https://www.wjgnet.com/1007-9327/full/v32/i35/121494.htm
DOI: https://dx.doi.org/10.3748/wjg.121494

Fan LW, Wu XZ, Liu ZW, Lin Q, Du JX, Tian YT, Dong XC, Xu DK. Tn antigen-driven downregulation of podoplanin promotes colorectal cancer invasion. World J Gastroenterol 2026; 32(35): 121494 [DOI: 10.3748/wjg.121494]

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