Matrix metalloproteinase 3 facilitates colorectal cancer progression by enhancing cell proliferation and invasion

Figure 1 Matrix metalloproteinase 3 is upregulated in colorectal cancer and associated with poor clinical outcomes. A: Analysis of matrix metalloproteinase 3 (MMP3) mRNA expression in colon adenocarcinoma tissues compared with normal adjacent tissues using The Cancer Genome Atlas (TCGA) data; B: MMP3 mRNA expression in rectal adenocarcinoma vs matched normal tissues based on the TCGA dataset; C: Reverse transcription-PCR analysis of MMP3 mRNA levels in 40 pairs of colorectal cancer (CRC) and matched adjacent normal tissues; D: Representative immunohistochemical (IHC) images displaying MMP3 expression in CRC and corresponding normal tissues; E: Quantitative analysis of IHC staining scores for MMP3 in 86 CRC samples from a commercial tissue microarray; F: Kaplan-Meier survival analysis based on IHC data indicates that elevated MMP3 protein expression correlates with reduced overall survival in CRC patients. MMP3: Matrix metalloproteinase 3; COAD: Colon adenocarcinoma; TCGA: The Cancer Genome Atlas; READ: Rectal adenocarcinoma; IHC: Immunohistochemical; HR: Hazard ratio.