Cladosporium cladosporioides ameliorates visceral hypersensitivity in irritable bowel syndrome-like mice by inhibiting dectin-1 signaling and mast cell activation

Figure 1 Administration of Cladosporium cladosporioides attenuated visceral hypersensitivity and gut motility in trinitrobenzene sulfonic acid-treated mice. A: Schematic diagram showing the timeline of model establishment, Cladosporium cladosporioides gavage, sample collection and behavioral observation; B: Visceral hypersensitivity in mice evaluated by CRD-AWR at 20, 40, 60, and 80 mmHg. Tow-way ANOVA; C: Fecal weight, frequency, and water content; D: Representative images of hematoxylin and eosin-stained tissues (n = 7). Scale bar = 100 μm. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. TNBS: Trinitrobenzene sulfonic acid.