Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications

doi:10.3748/wjg.119467

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 14, 2026; 32(34): 119467
Published online Sep 14, 2026. doi: 10.3748/wjg.119467

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Figure 4 Interleukin 33 signaling in the spleen. Diagram illustrates interleukin 33 (IL-33) signaling in splenic iron recycling, highlighting its role in red pulp macrophage maturation and erythrocyte clearance via the IL-1 receptor-like 1 (IL1RL1)-suppression of tumorigenicity 2 receptor pathway and downstream transcription factors GATA-binding factor 2 (GATA2) and Spi-C. RPM: Rat promegakaryoblast-like.

Citation: Tarantino G, Citro V. Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications. World J Gastroenterol 2026; 32(34): 119467
URL: https://www.wjgnet.com/1007-9327/full/v32/i34/119467.htm
DOI: https://dx.doi.org/10.3748/wjg.119467

Tarantino G, Citro V. Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications. World J Gastroenterol 2026; 32(34): 119467 [DOI: 10.3748/wjg.119467]

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