Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications

doi:10.3748/wjg.119467

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 14, 2026; 32(34): 119467
Published online Sep 14, 2026. doi: 10.3748/wjg.119467

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Figure 2 Line graph showing the trend of the spleen volume vs fibrosis in non-alcoholic fatty liver disease. Splenic volume generally increases in parallel with the progression of liver fibrosis, with the most significant increases often observed in the transition from F3 to F4, although this can be variable due to collateral circulation. NASH: Nonalcoholic steatohepatitis.

Citation: Tarantino G, Citro V. Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications. World J Gastroenterol 2026; 32(34): 119467
URL: https://www.wjgnet.com/1007-9327/full/v32/i34/119467.htm
DOI: https://dx.doi.org/10.3748/wjg.119467

Tarantino G, Citro V. Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications. World J Gastroenterol 2026; 32(34): 119467 [DOI: 10.3748/wjg.119467]

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