Urinary cell-free DNA as a noninvasive liquid biopsy for hepatocellular carcinoma

doi:10.3748/wjg.118587

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Sep 7, 2026; 32(33): 118587
Published online Sep 7, 2026. doi: 10.3748/wjg.118587

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Figure 4 Comparison of the 10 most frequent 5’ 4-mer end motifs of hepatitis B virus DNA fragments in plasma and in urine between hepatocellular carcinoma and non-hepatocellular carcinoma hepatitis B patients. A and B: The 10 most frequent 5’ 4-mer end motifs identified in plasma (A) and in urine (B) (top panel) and in the corresponding matched urine and plasma (bottom panel) from hepatocellular carcinoma (blue) and non-hepatocellular carcinoma (orange) patients are compared. Motifs are sorted by motif frequencies in the top panel. HCC: Hepatocellular carcinoma.

Citation: Kim AK, Lin SY, Liu HN, Jain S, Gade TP, Shieh FS, Hamilton J, Hann HW, Chang TT, Goryunov D, Wang Z, Su YH. Urinary cell-free DNA as a noninvasive liquid biopsy for hepatocellular carcinoma. World J Gastroenterol 2026; 32(33): 118587
URL: https://www.wjgnet.com/1007-9327/full/v32/i33/118587.htm
DOI: https://dx.doi.org/10.3748/wjg.118587

Kim AK, Lin SY, Liu HN, Jain S, Gade TP, Shieh FS, Hamilton J, Hann HW, Chang TT, Goryunov D, Wang Z, Su YH. Urinary cell-free DNA as a noninvasive liquid biopsy for hepatocellular carcinoma. World J Gastroenterol 2026; 32(33): 118587 [DOI: 10.3748/wjg.118587]

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