Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association

doi:10.3748/wjg.118486

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 7, 2026; 32(33): 118486
Published online Sep 7, 2026. doi: 10.3748/wjg.118486

Table 2 Characteristics of colorectal adenomas with or without chicken skin mucosa, n (%)

Characteristic	Adenoma with CSM (n = 130)	Adenoma without CSM (n = 2107)	OR (95%CI)	P value
Size (cm)	1.0 (1.0, 1.5)	0.5 (0.5, 0.6)	-6.968 (-8.187 to -5.749)	< 0.001
Morphology			11.715 (2.884-47.585)	< 0.001
Flat (IIa, Is, LST)	2 (1.5)	326 (15.5)
Protruding (Ip, Isp)	128 (98.5)	1781 (84.5)
Location			7.958 (4.854-13.004)	< 0.001
Proximal colon	19 (14.6)	1215 (57.7)
Distal colon	111 (85.4)	892 (42.3)
Histology				< 0.001
Tubular adenoma	61 (46.9)	2065 (98.0)	-
Villous or tubulovillous adenoma	39 (30.0)	24 (1.1)
High-grade neoplasia	30 (23.1)	18 (0.9)
Adenoma type			71.757 (43.325-118.846)	< 0.001
Non-advanced adenoma	20 (15.7)	1957 (92.9)
Advanced adenoma	110 (84.3)	150 (7.1)

CI: Confidence interval; CSM: Chicken skin mucosa; OR: Odds ratio; LST: Laterally spreading tumor.

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Citation: Wang RJ, Hu Y, Guo SB. Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association. World J Gastroenterol 2026; 32(33): 118486
URL: https://www.wjgnet.com/1007-9327/full/v32/i33/118486.htm
DOI: https://dx.doi.org/10.3748/wjg.118486

Wang RJ, Hu Y, Guo SB. Chicken skin mucosa is independently associated with advanced colorectal adenoma with transmembrane member 16A potentially involved in this association. World J Gastroenterol 2026; 32(33): 118486 [DOI: 10.3748/wjg.118486]

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